PUBLICATIONS

Our authored documents, platform science, neo-organ application, and other clinical information are detailed in our publications section below.  If you have any questions about our papers, please contact us.

Clinical

Renal autologous cell therapy (REACT) to stabilize function in diabetes-related chronic kidney disease: corroboration of mechanism of action with cell marker analysis

Kidney Intl Reports.  April 11, 2022. DOI: https://doi.org/10.1016/j.ekir.2022.04.014

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Joseph Stavas, MD, MPH, Guido Filler, MD, PhD, Deepak Jain, PhD,

John Ludlow, PhD, Joydeep Basu, PhD, Richard Payne, PhD, Emily Butler, PhD

Maria Díaz-González de Ferris, MD, PhD, MPH, and Tim Bertram, PhD

Clinical

Novel Renal Autologous Cell Therapy (REACT) for Type 2 Diabetes Mellitus Chronic Diabetic Kidney Disease: Clinical Trial Design

American Journal of Nephrology. Jan 14, 2022, https://doi.org/10.1159/000520231

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Joseph Stavas, David Gerber, Steven G. Coca, Arnold L. Silva, Ashley Johns, Deepak Jain, Tim Bertram, Maria Díaz-González de Ferrise, George Bakris

Clinical

Protocol and baseline data on renal autologous cell therapy injection in adults with Chronic Kidney Disease secondary to Congenital Anomalies of the Kidney and Urinary Tract

Blood Purification, March 1, 2021 DOI: 10.1159/000512586

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Joseph Stavas, Maria Diaz-Gonzalez de Ferris, Ashley Johns, Deepak Jain, Tim Bertram

Clinical

SAFETY AND FEASIBILITY OF A NOVEL PERCUTANEOUS LOCOREGIONAL INJECTION TECHNIQUE OF RENAL CELLULAR THERAPY FOR CHRONIC KIDNEY DISEASE OF DIABETES

Safety and Feasibility of a Novel Percutaneous Locoregional Injection Technique of Renal Cellular Therapy for Chronic Kidney Disease of Diabetes

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Hyeon Yu , Paul D. Sonntag , Peter R. Bream , Michael P. Lazarowicz, Francis S. Nowakowski, Gregory J. Woodhead, Charles T. Hennemeyer, Ryan D. Muller, Rakesh Navuluri, Elaine M. Caoili, Aaron C. Eifler, Brandon S. Tominna and Joseph M. Stavas

Clinical

RENAL AUTOLOGOUS CELL Therapy/NEO-KIDNEY AUGMENT TM (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPLANTATION IN Type 2 DIABETES WITH CHRONIC KIDNEY DISEASE

Renal Autologous Cell Therapy/Neo-Kidney AugmentTM (REACT/NKA): Phase II study of REACT/NKA implantation In Type 2 Diabetes with Chronic Kidney Disease

Joseph Stavas, Tim Bertram, Ashley Johns, Deepak Jain, David Gerber, Prabir Roy-Chaudhury, George Bakris

Clinical

RENAL AUTOLOGOUS CELL THERAPY/NEO-KIDNEY AUGMENT TM (REACT/NKA): PHASE II STUDY OF REACT/NKA IMPANTATION IN TYPE 2 DIABETES WITH PRE-STAGE 5 CHRORIC KIDNEY DISEASE

Renal Autologous Cell Therapy/Neo-Kidney AugmentTM (REACT/NKA): Phase II study of REACT/NKA implantation in Type 2 Diabetes with Pre-Stage 5 Chronic Kidney Disease

Joseph Stavas, Tim Bertram, Deepak Jain, Ashely Johns, David Gerber, Prabir Roy-Chaudhury , George Bakris

Clinical

IMPLANTATION OF AUTOLOGOUS SELECTED RENAL CELLS IN DIABETIC CHRONIC KIDNEY DISEASE STAGES 3 AND 4—CLINICAL EXPERIENCE OF A “FIRST IN HUMAN” STUDY

Implantation of Autologous Selected Renal Cells in Diabetic Chronic Kidney Disease Stages 3 and 4—Clinical Experience of a “First in Human” Study

Peter Stenvinkel, Jonas Wadström, Tim Bertram, Randal Detwiler, David Gerber,
Torkel B. Brismar, Pontus Blomberg and Torbjörn Lundgren

Pre-Clinical

A POPULATION OF SELECTED RENAL CELLS AUGMENTS RENAL FUNCTION AND EXTENDS SURVIVAL IN THE ZSF1 MODEL OF PROGRESSIVE DIABETIC NEPHROPATHY

A Population of Selected Renal Cells Augments Renal Function and Extends Survival in the ZSF1 Model of Progressive Diabetic Nephropathy

Rusty Kelley, Andrew Bruce, Tom Spencer, Eric Werdin, Roger Ilagan, Sumana Choudhury, Elias Rivera, Shay Wallace, Kelly Guthrie, Manuel Jayo, Fengfeng Xu, Anjali N. Rao, Benjamin D. Humphreys, Sharon Presnell and Tim Bertram

Pre-Clinical

A TUBULAR CELL-ENRICHED SUBPOPULATION OF PRIMARY RENAL CELLS IMPROVES SURVIVAL AND AUGMENTS KIDNEY FUNCTION IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE.

Kelley R., Werdin E.S., Bruce A.T., Choudhury S., Wallace S.M., Ilagan R.M., Cox B.R., Tatsumi-Ficht P., Rivera E.A., Spencer T., Rapoport H.S., Wagner B.J., Guthrie K., Jayo M.J., Bertram T.A., Presnell S.C. (2010, September 8). 
Tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in rodent model of chronic kidney disease

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Am J Physiol Renal Physiol (September 8, 2010). doi:10.1152/ajprenal.00221.2010

Pre-Clinical

MOLECULAR CHARACTERIZATION OF THE REGENERATIVE RESPONSE INDUCED BY INTRARENAL TRANSPLANTATION OF SELECTED RENAL CELLS IN A RODENT MODEL OF CHRONIC KIDNEY DISEASE

Genheimer, W.G., Ilagan R.M., Spencer T., Kelley R., Werdin E., Choudhury S., Jain D., Ludlow J.W., Basu J. (2012). Molecular Characterization of the Regenerative Response Induced by Intrarenal Transplantation of Selected Renal Cells in a Rodent Model of Chronic Kidney Disease. Cells Tissues Organs 2012;196:374–384

Pre-Clinical

FUNCTIONAL EVALUATION OF PRIMARY RENAL CELL/BIOMATERIAL NEO-KIDNEY AUGMENT PROTOTYPES FOR RENAL TISSUE ENGINEERING

Basu J., Genheimer C.W., Rivera E.A., Payne R., Mihalko K., Guthrie K., Bruce A.T., Robbins N., McCoy D., Sangha N., Ilagan R., Knight T., Spencer T., Wagner B.J., Jayo M.J., Jain D., Ludlow J.W., Halberstadt C. (2011, March). Functional evaluation of primary renal cell/biomaterial Neo-Kidney Augment prototypes for renal tissue engineering Cell Transplant. 2011 Mar 24. doi: 10.3727/096368911X566172.

Pre-Clinical

ISOLATION, CHARACTERIZATION, AND EXPANSION (ICE) METHODS FOR DEFINED PRIMARY RENAL CELL POPULATIONS FROM RODENT, CANINE, AND HUMAN NORMAL AND DISEASED KIDNEYS.

Presnell S.C., Bruce A.T., Wallace S.M., Choudhury S., Genheimer C., Cox B., Guthrie K.I., Werdin E.S., Tatsumi-Ficht P., Ilagan R., Kelley R.W., Rivera E.A., Ludlow J.W., Wagner B.J., Jayo M.J., Bertram T. (2010, September 16) Isolation, Characterization, and Expansion (ICE) Methods for Defined Primary Renal Cell Populations from Rodent, Canine, and Human Normal and Diseased Kidneys.Tissue Eng Part C Methods. 2010 Sep 16.

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